Recently, a number of philosophers of biology have endorsed views about random drift that, we will argue, rest on an implicit assumption that the meaning of concepts such as drift can be understood through an examination of the mathematical models in which drift appears. They also seem to implicitly assume that ontological questions about the causality of terms appearing in the models can be gleaned from the models alone. We will question these general assumptions by showing how the same equation (...) — the simple 2 = p2 + 2pq + q2 — can be given radically different interpretations, one of which is a physical, causal process and one of which is not. This shows that mathematical models on their own yield neither interpretations nor ontological conclusions. Instead, we argue that these issues can only be resolved by considering the phenomena that the models were originally designed to represent and the phenomena to which the models are currently applied. When one does take those factors into account, starting with the motivation for Sewall Wright’s and R.A. Fisher’s early drift models and ending with contemporary applications, a very different picture of the concept of drift emerges. On this view, drift is a term for a set of physical processes, namely, indiscriminate sampling processes. (shrink)

Hospital systems commonly face the challenge of determining just ways to allocate scarce drugs during national shortages. There is no standardised approach of how this should be instituted, but principles of distributive justice are commonly used so that patients who are most likely to benefit from the drug receive it. As a result, clinical indications, in which the evidence for the drug is assumed to be established, are often prioritised over research use. In this manuscript, we present a case of (...) a phase II investigational trial of intravenous thiamine for delirium prevention in patients undergoing haematopoietic stem cell transplantation to emphasise several shortcomings in the overarching prioritisation of clinical over research uses of scarce drugs. Specifically, we present the following considerations: clinical use may not have stronger evidence than research use; a strong scientific rationale for research use may outweigh the claim for clinical indications in which there is weak evidence; treatment within the context of a clinical trial may be the standard of care; and research use may not only benefit patients receiving the treatment but also offers the prospect of improving future clinical care. In summary, we argue against allocation schemes that prohibit all research uses of scarce drugs and instead recommend that allocation schemes include a balanced approach that weighs risks and benefits of access to scarce drugs irrespective of the research versus clinical use designation. (shrink)

This is an edited collection containing papers on intrinsic value, consequentialism, the evil of death, among others.

_Addresses of the Mississippi Philosophical Association_ is a collection of presidential and invited addresses from the members of the Mississippi Philosophical Association (MPA). Papers date from the inception of the association in the mid-1940s and continue through 1999. The common thread in these addresses is the authors' service to or leadership in the MPA. The content and methods in the chapters are diverse, including addresses on ethics, political philosophy, history of philosophy, epistemology, aesthetics, philosophy of language, philosophy of religion, philosophy (...) of science, and philosophical theology. Some unique features of this book are a history of the MPA, biographical sketches and photographs of each contributor, and the inclusion of the unpublished 1988 Dunbar Lectures from Millsaps College and the unpublished 1992 Akin Lecture from Mississippi College. These essays and lectures reveal the vitality of philosophy in the colleges and universities of Mississippi. As part of the special series, Histories and Addresses of Philosophical Societies in the larger Value Inquiry Book Series, this book documents - in a unique historical format - the value and vitality of a state philosophical organization. “There has been no attempt to mold these addresses into a unity; rather, the addresses offer a glimpse of the pluralistic philosophical reflection among the philosophical faculties of the private colleges and public universities in the state of Mississippi. To the surprise of some people, philosophy is alive, well, diverse, and flourishing in Mississippi!” (from the Preface). (shrink)

WITHTHE OVERWHELMINGLY DISPROPORTIONATE NUMBER OF BLACK MEN on death row, some argue that today's death penalty executions in the United States are the equivalent of legalized lynching. Others may charge this equivalence as hyperbole, but the numbers betray a system of racialized injustice that people of good will ought to reject today as did like-willed people of the churches, synagogues, and community organizations of the years leading up to the civil rights movement and beyond. This essay exposes the factors of (...) race and poverty that lead to determinations of the guilt or innocence and the likelihood of a death or life sentence to those convicted of capital crimes. (shrink)

Constructive engagement in international business practice is defined as purpose-driven behavior in which economic contributions by the foreign investor also advance social progress in the host country. This paper distinguishes between amoral and moral social agency, and proposes a model of principled constructive engagement that describes a principled constructive engagement regime enacted in a disciplined, morally-directed manner.